However, there is a high prevalence in impaired fasting glucose, requiring attention from policymakers to take action to prevent the occurrence of the epidemic of type 2 diabetes in children in the future. The prevalence of type 1 and type 2 diabetes in children in Vietnam is lower than that in some other countries reported recently. Body mass index, place of residence, and age were found to be significantly associated with the impaired fasting glucose condition in participants. The prevalence of impaired fasting glucose was 6.1%. The overall prevalence of diabetes among the participants was 1.04‰ (three cases), with 2 cases (0.75‰) diagnosed with type 1 diabetes (one known and one newly diagnosed) and 1 case newly diagnosed with type 2 diabetes (0.35‰). Multivariate logistic regression was used to examine the association between outcome and independent variables. Additionally, anthropometric and blood pressure measurements were conducted following a standardized procedure. Diabetes status and type of diabetes of participants were confirmed at a hospital. Diabetes and impaired fasting plasma glucose were initially diagnosed based on the cut-off points of the American Diabetes Association criteria. Capillary blood samples of participants were collected to measure fasting glucose level, using glucose meter OneTouch Verio Pro+. This study is aimed at estimating the prevalence of type 1 and type 2 diabetes and prediabetes among children in Vietnam and examining factors associated with the conditions.Ī total of 2880 students aged 11-14 years old were recruited for the survey, using a school-based and nationally representative sampling frame. However, in most countries, little is known about the epidemiology of this disease. Future research is needed to investigate large-scale functional networks in association with both excitatory and inhibitory metabolites in subpopulations of ASD.Diabetes in children is becoming more prevalent in some countries. We provided new evidence to support the excitatory-inhibitory imbalance theory, where excitatory Glx concentrations were related to functional dysconnectivity in ASD. In contrast, HC displayed a positive relationship between the same metabolite and connectivity measures. Individuals with ASD showed significantly negative associations between increased Glx concentrations and reduced functional connectivity between the dACC and insular, limbic and parietal regions. Finally, metabolite concentrations were related to functional connectivity coefficients and compared between both groups. Seed-based functional connectivity was analyzed with a priori seeds of the right and left dACC. Glu and Glx concentrations were compared between groups.
Nineteen adult males with ASD and 19 age and sex-matched healthy controls (HC) (23 - 58 years) underwent Proton Magnetic Resonance Spectroscopy of the dorsal anterior cingulate cortex (dACC) and resting-state functional Magnetic Resonance Imaging (fMRI). Here, we investigated the excitatory-inhibitory imbalance theory by measuring Glu-concentrations and the relationship with resting-state function. It has been proposed that the Glutamate (Glu) system is implicated in autism spectrum disorders (ASD) via an imbalance between excitatory and inhibitory brain circuits, which impacts on brain function.
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